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This inactivation disrupts key enzymatic reactions, including the conversion of methylmalonyl-CoA to succinyl-CoA by methylmalonyl-CoA mutase and the synthesis of methionine from homocysteine (Hcy) by methionine synthase (Figure 2)
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Inhibiting this pathway leads to enhanced fat metabolism and improved glucose tolerance. Hong et al., Nature Medicine Biohackers and Longevity Enthusiasts Because it increases NAD a key coenzyme in energy metabolism, DNA repair, and aging 5-Amino-1MQ may appeal to those looking to extend healthspan, improve cellular resilience, and combat age-related decline
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