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For the treatment-regimen estimand, the mean body weight reductions from baseline at 72 weeks were 15.0%, 19.5%, and 20.9% in the tirzepatide 5, 10, and 15 mg groups, respectively, versus 3.1% in the placebo group
Stotland Mitchell is a board-certified Occupational Medicine physician with 5+ years of experience
In fact, a 2025 study published in JAMA cites steep list prices (over $1000 a month) and spotty insurance coverage as top reasons why most people seeking to lose weight quit taking meds like Ozempic or Vaxenda within a year
Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial
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