Specifically, it improves HbA1c levels (an indicator of long-term blood sugar control) and insulin resistance (meaning your cells can use insulin more effectively, leading to less glucose storage and lower blood glucose levels).19 According to a 2021 animal study, berberine supplementation can slow the progression from prediabetes to type 2 diabetes.20 Some studies also suggest that taking berberine in addition to prescription medication like metformin could result in greater glycemic control;21 more definitive research is needed to support this theory, but even newer studies have found berberine to have this assistive effect.54 Also, its worth noting that berberine could potentially be a good alternative for people who cant take diabetes medication due to liver, kidney, or heart disease

Improved Cardiometabolic Parameters: Pemvidutide resulted in robust reductions in serum lipids and improvements in blood pressure without imbalances in cardiac events, arrhythmias, or clinically meaningful increases in heart rate
You develop symptoms such as persistent nausea, oedema, joint pain, or fatigue whilst using any unlicensed compound
Its not just price that is making people consider alternatives