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The definitive impact of tirzepatide on cardiovascular disease will be addressed in the ongoing SURPASS-COVT study (ClinicalTrials.gov number, NCT04255433), which compares tirzepatide with dulaglutide in patients with T2DM and ASCVD

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Using logistic regression models, they estimated propensity scores that incorporated demographics, comorbidities, immunosuppressive medication use, COVID-19 vaccination, and prior infection, and subsequently performed inverse probability treatment weighting (IPTW)

Our experience working with research labs suggests that the most successful protocols involve building the injection timing into an existing evening routine