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Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan

Patients typically begin with a lower dose and gradually increase over several weeks based on tolerance and weight loss response

GLP-1RAs excel at inducing short-term weight loss by imposing a powerful external satiety signal, whereas postbiotics may contribute to stabilizing the endogenous signaling environment that governs appetite regulation and metabolic adaptation ( Adipose tissue plasticity and thermogenic capacity: BAT, browning, and the physiological ceiling in humans The discovery of metabolically active BAT in adult humans raised expectations that obesity therapies might meaningfully increase energy expenditure through thermogenesis ( In humans, however, BAT mass is limited, heterogeneous, and reduced in obesity, and even maximal activation contributes only modestly to total energy expenditure ( Importantly, the physiological ceiling on BAT-mediated thermogenesis implies that increasing energy expenditure is unlikely to offset the metabolic adaptation associated with rapid weight loss

iNOs/NO pathway It has been found that ferroptosis plays a role in different mammalian cells, but some specific types of cells, especially cells of the innate immune system (such as macrophages), show significant resistance to ferroptosis [44]