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A 10-year longitudinal follow-up of a retrospective cohort comprising 159 patients with PCOS treated with metformin reported that the total testosterone and androstenedione decreased to 15.4 47.9% and 11.3 46.4% within first year, with further decrease in total testosterone and androstenedione to 37.8 61.8 and 24.8 40.5% at the fifth year of the follow-up (38, 39)
All of which get blamed on the medication when the real cause is simply not drinking enough water
Increased Energy Levels Less extra weight means more stamina
It will be important to see and compare real-world experiences [and evaluate] efficacy, because right now we are sort of assuming and looking at this through the lens of the trial patients. With regard to the next-generation agents that Heffron referenced, Hurtado Andrade said while the GLP-1 agonists do have a 20-year history of safe use in diabetic patients, as we develop newer versions of these medications, they tend to be more potent
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