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Single-cell RNA sequencing further revealed a shift toward osteogenic lineages, cartilage progenitor cells and pre-osteoblasts, underscoring hMSC-E4s capacity to accelerate chondrogenic maturation and endochondral bone formation [26]

Preclinical animal studies evaluating related metabolic peptides have reported dosing ranges in the microgram per kilogram (g/kg) scale depending on the experimental objective