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Further evidence has increased the understanding of GIP showing that GIP likely still has a role in diabetes despite normal or sometimes elevated concentrations
Anti-IGF-1 receptor (IGF-1R) monoclonal antibodies (mAbs) were developed for clinical use in treating advanced stage cancers 22,23,24 , including Ganitumab, which remains under investigation as a combination therapy in clinical trials targeting Rhabdomyosarcoma (NCT03041701) and Ewing Sarcoma (NCT02306161), for which it recently received orphan drug status
Examples include: Medical contraindications to GLP-1 therapy Lack of clinical supervision No structured plan for muscle preservation Hormonal status not yet evaluated Reducing the dose does not remove contraindications or eliminate underlying medical risks
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