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Gastroenterology 141:150156 Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC (2012) Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model
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However, OSA is an FDA-approved indication for Zepbound (tirzepatide) outside the Bridge, based on the SURMOUNT-OSA trial
This in turn has led to diabetes GLP-1 medications being prescribed off-label to promote weight loss in obese and overweight patients
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