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Free radicals, such as reactive oxygen species, and the mitochondria are physiologically connected

In the future, developing more specific antibodies, integrating Top-Down proteomics strategies, and creating smarter algorithms to decipher complex combinatorial modifications will be key to advancing the field

Because IL-1 immediately responds to a wide diversity of pro-inflammatory insults and affects the function of many targets, it is essential to limit the potentially harmful aspects of inflammation by negatively regulating IL-1 expression [92]