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IGF-1 promotes cell proliferation and tissue growth, which raises theoretical concerns about tumor growth or cancer risk, especially in individuals with pre-existing tumors or a family history of cancer
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Microglia in ALS spinal cords exhibited increased expression of ALOX5 and LPCAT3, indicating dysregulated iron metabolism and activation of ferroptosis
Talking to investors on an earnings call in February, Pfizer Chief Scientific Officer Chris Boshoff, M.D., Ph.D., said the molecule could form part of a fixed-dose combination with danuglipron
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