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Calling these established uses overstates it
As mentioned, glutathione production is influenced by a number of factors
CB-839 resistant breast cancer cell line (but not their parental cells) showed down-regulated glutamine consumption and requires exogenous asparagine in cell culture medium for proliferation, implying glutamine independence in cancer cells may be related to the switch to asparagine pathway in order to reach the cellular demand for survival [65]
Thus, the ratio of GSH to GSSG is largely considered a marker of oxidative stress [8, 32]
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