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A pilot study subsequently conducted by Holst in collaboration with Mette Zander at Hvidovre Hospital between September 1999 and October 2000 indicated that continuous subcutaneous infusions of synthetic GLP-1 over 6 weeks into patients with quite severe type 2 diabetes dramatically improved their blood sugar control, lowered glycated haemoglobin levels and decreased their body weight

These medicines can help with blood sugar control and weight loss, but they can also cause digestive symptoms and, in some cases, more serious complications that need quick medical evaluation

10.1074/jbc.M609088200 J

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