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And hepatic steatosis resolved in greater than 85% of participants with retatrutide 8 mg and 12 mg at week 48. The safety profile of retatrutide in the NAFLD subset was similar to that in the obesity population, and no hepatotoxicity signals in obesity or NAFLD was seen through week 48

Semaglutide, tirzepatide, and retatrutide (Biosynth, Compton, UK, lot #s 0000042482, 0000054911, and 0000205204 respectively) were dissolved in 0.3% phosphate-buffered saline (PBS), which was adjusted to a pH of 8.0 using NaOH and injected subcutaneously (s.c.) at 1 ml/kg