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Tirzepatide (Mounjaro, Zepbound), a dual GIP/GLP-1 receptor agonist, reports injection site reaction rates of approximately 1.7-2.2% in its FDA prescribing information, similar to semaglutide

While peptide therapy may possess significant therapeutic and regenerative potential, it is critical that orthopedic and sports medicine providers understand the current lack of evidence to support the clinical use of these peptides, the authors concluded

They must be paired with other group health coverage, so only employees (and enrolled spouses/dependents) in that coverage can use the HRA