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In the United States, patients usually receive vitamin B 12 injections of 1 mg/d in their first week of treatment

It has a genuine FDA-approval history rather than being a novel "research chemical," but no FDA-approved finished product remains on the market, so it is supplied only through compounding pharmacies and prescribed off-label in adults for growth-hormone-axis support, general wellness, or anti-aging purposes rather than its original pediatric indication

However, a few studies have suggested that these actions of the trefoil peptides may also contribute to the movement of cancer cells, known as metastasis, in cell models

Older adults may experience decreased absorption of B12 due to changes in the acids and enzymes required for its absorption