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Positive chronotropic and inotropic effects in heart failure have been demonstrated with infusions of GLP-1 in animal studies and small short-term studies of patients with acute heart failure post-myocardial infarction and in patients with chronic systolic and diastolic dysfunction.12 Tirzepatide has demonstrated additional benefits of slowing renal decline when used in conjunction with insulin and reduced all-cause mortality compared with other GLP-1RAs.13 In patients with type 2 diabetes mellitus (T2DM), reductions in composite renal outcomes and renal failure have been outlined in meta-analyses.14 Of great interest for gastroenterologists and hepatologists is the potential for using GLP-1 agonists in metabolic dysfunction-associated steatotic liver disease (MASLD)