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This 23-atom macrocycle constrains the central His-D-Phe-Arg-Trp recognition motif into the receptor-binding conformation, eliminating the entropic cost normally associated with binding linear peptides and enhancing the affinity for melanocortin receptors
doi: 10.1105/tpc.110.079269 18 Fuentes-UgarteNPereira-SilvaMCortes-RubilarIVallejos-BaccelliereGGuixVCastro-FernandezV
Weissferdt A, Pataer A, Vaporciyan AA, Correa AM, Sepesi B, Moran CA, Wistuba II, Roth JA, Shewale JB, Heymach JV, Kalhor N, Cascone T, Hofstetter WL, Lee JJ, Swisher SG
P., Olpin, S
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