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Part of it is due to the rapid weight loss and part of it is possibly a lack of proper nutrition in patients taking these medications, says John Diaz, MD, a plastic surgeon in Beverly Hills, CA

In the LEAN trial, a small phase 2b trial, treatment with 1.8 mg/day liraglutide resulted in a histologic resolution of NASH and a decreased progression of fibrosis [27]

The goal is combining these three pathways to produce greater weight loss than current medications that only target one or two of these receptors