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HEL and LPO levels were measured using an HEL enzyme-linked immunosorbent assay (ELISA) kit and LPO assay kit (Japan Institute for the Control of Aging, Nikken SEIL Co

Cold exposure has been practiced for centuries without identified chronic harms in otherwise healthy individuals

The continuous hyperglycemia can induce target organ damage (TOD) by increasing the risk of panvascular disease, including microvascular disease (such as diabetic retinopathy, nephropathy and neuropathy), and atherosclerotic macrovascular disease (cardiovascular, cerebrovascular, and other peripheral vascular diseases)