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It simultaneously activates three key metabolic receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and the receptor at glucagon This triple synergistic action makes it one of the most studied peptides in research on obesity and metabolic disorders

Discontinuation rates due to adverse events in TRIUMPH-3 were 9.8% (9 mg) and 13.5% (12 mg) with retatrutide, compared with 4.8% for placebo

GLP-1 therapy requires sustained monitoring for pancreatitis risk, dehydration, rapid weight loss complications, and medication interactions

In addition, the stress caused by persistent night sweats can lead to elevated cortisol levels