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One of the main identified targets is the nitric oxide (NO) pathway, where the peptide acts as a modulator of NO synthesis via NO synthase (NOS) enzymes

The peaks are lower, so side effects should theoretically be milder

Following a single oral 100-mg dose to healthy volunteers, mean plasma AUC of sitagliptin was 8.52 Mhr, Cmax was 950 nM, and apparent terminal half-life (t) was 12.4 hours