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Briefly, when muscle is injured, overused, or mechanically stretched, satellite cells are activated to enter the cell cycle through a cascade of events including nitric oxide (NO) radical-dependent release of the active form of HGF (a hetero-dimer of - and -chains) from its extracellular tethering and the subsequent presentation of HGF to the cell-membrane signaling receptor c-met, followed by the sequence of steps including proliferation to produce myoblast progeny, differentiation, and fusion with existing muscle fibers and/or to form new fibers 18,19,20,21,22, 31

It is also FDA approved to lower the risk of major cardiovascular events (such as death, heart attack, or stroke) in adults with heart disease and either obesity or overweight

TLR, Toll-like Receptor

NICE guidance on obesity management (CG189) emphasises the importance of nutritional adequacy during pharmacological weight loss interventions