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GLP-1 is rapidly broken down and inactivated by the enzyme dipeptidyl peptidase-4 (DPP4), which is distributed throughout the body, both on the surface of cell membranes, and free in the bloodstream
In August 2025, generic liraglutide was approved for weight loss
The efficacy and safety of tirzepatide, with a special focus on cardiovascular safety, were investigated in the 52-week SURPASS-4 trial testing tirzepatide versus insulin glargine in adults with T2D and a high cardiovascular risk under inadequate glycemic control at baseline on one to three oral glucose-lowering medications (metformin, sulfonylurea, SGLT-2 inhibitor) (74)
nitric-oxide signaling
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