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Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling
Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, et al
C.VallisM.SharmaA
Significant weight loss may unmask or alter thyroid status, requiring minor levothyroxine dose adjustments
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