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Patients who reach their highest effective dose by week 12 often sustain steady weight loss for months afterward, provided behavioral and nutritional foundations remain solid
However, the available data remain heterogeneous, frequently reliant on surrogate endpoints, and rarely tested in clinical settings reflective of orthopaedic surgical care (Rahman et al
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![PDF] Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial](https://figures.semanticscholar.org/d41b60396b3e16265d197d5dae49fdcd493f4490/7-Figure2-1.png)
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