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Structures of the most potent compounds described herein (2, 23, and 50) and several previously described TGR inhibitors ((I), (II), and (III)) ([13], [14])

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The GC oven was set to hold at 50 C for 1 min, then ramp to 20 C/min to 330 C, then held for 5 min

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Fix: Start with 2030 mcg/day and assess tolerance over 12 weeks

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