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Multi-omics studies revealed that SARS-CoV-2 infection provokes significant changes in numerous metabolites including those impacting on virus propagation (one-carbon metabolism) and GSH synthesis (amino acids glutamic acid, cysteine and glycine) that could be used as early prognosis biomarkers in COVID-19 at diagnose to predict severe COVID-19 and LONG COVID (Doan et al., 2021
Adv Mater 33:2007247
Glutathione suppresses production of melanin-producing substances and also changes existing melanin to light-colored pheomelanin
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