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In addition, berberine can induce activation of PI3K/AKT signaling pathway, which is related to Nrf2 expression and neuroprotection (Zhang et al., 2017)

But the arrival of GLP-1 (glucagon-like peptide-1) receptor agonists changed everything

A 2025 Stanford Medicine study identifying a naturally occurring peptide that suppressed appetite and reduced body weight without the nausea and muscle loss associated with semaglutide confirmed what many clinicians had already observed: the GLP-1 mechanism is powerful, but it carries side effects tied directly to how it works

Well discuss this during your consultation and can recommend you speak to your GP about comprehensive blood work if needed