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Wegovy (semaglutide) The STEP program demonstrates robust weight loss with lifestyle intervention

Why GLP-1s Are Revolutionary: Historical Context: Before GLP-1 medications: Weight loss medications produced 3-7% average weight loss Only bariatric surgery achieved 15-30% weight loss Many people couldnt access surgery due to cost, risk, or preferences Gap existed between ineffective pills and invasive surgery GLP-1s filled this gap: Producing 10-22% weight loss with medication alone Non-surgical option with bariatric-level results Relatively few contraindications Once-weekly administration Generally well-tolerated How GLP-1 Medications Work: Natural Hormone Mimicry: GLP-1 is a hormone your body naturally produces in your intestines after eating

It incorporates a functional maleimido group at the C-terminus that allows it to covalently bind plasma proteins such as serum albumin

DNA sequencing demonstrated that the insertion sequence was correct