For example, type 2 diabetes increases FA uptake and oxidation in the heart (Rijzewijk et al., 2009), high salt-induced cardiac hypertrophy was associated with no changes in FA metabolism (Grover-McKay et al., 1989), and dilated cardiomyopathy was associated with decreased FA oxidation (Dvila-Romn et al., 2002)
I n skeletal muscle, IGF1R activation sensitizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as mediating this rapid turnover of IRS1, since IRS1 loss can be rescued by knockdown of Fbxo40
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Singh R, Verma R, Sati N, Ansari WA, Khan MF