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For certain analyses, participants from the HC and SCD groups were combined into a single group of cognitively normal (CN), while those with MCI and dementia were grouped together into a cognitively impaired (CI) group
doi: 10.1111/j.1365-313X.2011.04853.x 8 CarvalhoF
The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007
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