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doi:10.3390/ejihpe12030024
4.2 GLP-1-based agents The focus of GLP-1RA development has predominantly been on designing GLP-1 derivatives resistant to DPP-4 enzymatic activity and exhibiting slow renal clearance through chemical modification and pharmaceutical formulation
Amycretin from Novo Nordisk combines GLP-1 and amylin receptor activation in a single molecule (unlike CagriSema which uses two separate molecules)
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Reduced inflammation from weight loss itself may also lower anxiety-related biomarkers, creating a secondary benefit independent of direct brain receptor activation
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