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Comparative proteomics analysis of 24 hpi trophozoite-stage MRA1240 (R539T PfK13 mutation) and MRA1239 (artemisinin sensitive isolate) isolates from Western Cambodia showed that the only consistently significantly dysregulated protein was PfK13 (Fig 1C, Supp Fig 1 and Supp data sheet 2)
it's a critical decision driven by the peptide's unique amino acid sequence
Mihm, M
At 20mg/mL, doses from 2mg to 12mg all fit in one draw, making it the most versatile concentration for a full dose escalation schedule
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