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The enzyme NNMT normally changes nicotinamide, a form of vitamin B3, by using methyl groups, which lowers nicotinamide adenine dinucleotide (NAD+) levels
Label-listed effects can include mild digestive upset, nausea, diarrhea, headache, or irritation related to a nasal or injectable product
Learn where to self-administer a B12 shot and how to do it painlessly This article was medically reviewed by Shari Forschen, NP, MA and by wikiHow staff writer, Amber Crain
| 07.22.25 | 3 min read
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