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Additionally, early controversy arose from questions about the detectability of irisin in human plasma using available immunoassays, with some studies questioning whether the signal reflected irisin or cross-reactive proteins

For example, a 2025 study in the Journal of the American Medical Association (JAMA) found people taking Ozempic were about 1.8 times as likely to experience vision loss from NAION, than those prescribed other diabetes medications

Tab 2: False positives used to filter the proteomic data (described in Methods)