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Eli Lilly's Phase 3 obesity programme for retatrutide (master protocol J1I-MC-GZBJ) remains in active follow-up with no NDA (New Drug Application) or MAA (Marketing Authorisation Application) filing recorded in 20242026 pipeline disclosures [1][2]
Clinical trials have included both male and female participants, with some notable observations: Metabolic differences Men typically have higher baseline metabolic rates and different fat distribution patterns, which may influence response magnitude but not optimal dosing protocols
It is a complex treatment that needs careful handling and regular checks
Emerging evidence indicates that lipid traits may have a role in DR as well, though work to understand this mechanism is still being conducted [79]
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