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Performing randomized controlled clinical trials on the timescales required for long-term outcomes as osteoporotic fractures is often not feasible in a general population not otherwise at high risk of fractures

What would combining the two drugs actually add mechanistically

Unfortunately, we were unable to harvest sufficient A2780DPP/GSTP1 knockdown cells to perform western blotting, cytotoxicity assays or more detailed phenotypic characterisation, but our confirmation of GSTP1 knockdown, together with selective platinum toxicity in puromycin-resistant clones is consistent with an essential role for GSTP1 in glutathione conjugation and cisplatin detoxification

Bays Researchers enrolled 176 adults with obesity or overweight plus one weight-related comorbidity