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In LPS-induced lung injury, mannose-modified generation 3 (G3) phosphodendrimer polymers can bind to activated dendritic cells (DCs) and ameliorate lung inflammation by inhibiting the proinflammatory cytokine TNF- in DCs (Li et al., 2022)

This comparison is arguably the most important in metabolic medicine heading into 2026, as it pits the two pharmaceutical giants against each other in the competition for the best-in-class obesity treatment