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The Food and Drug Administration declared the shortage over in 2025, yet telehealth companies still sell compounded versions of the anti-obesity drugs, tailoring the medications to different dosages and often selling them for less than what pharmaceutical companies charge for the brand-name drugs

Additionally, tirzepatide (Mounjaro, Zepbound) represents a dual GIP/GLP-1 receptor agonistnot a GLP-1 receptor agonistavailable for both diabetes management and weight loss, depending on the brand and indication

Consistent with this, Syn 1103 transgenic mouse models exhibit compact aggregates in TH-positive dopaminergic neurons of the substantia nigra and show increased vulnerability due to enhanced Syn 1103 toxicity 54