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The trial data above reflects outcomes at full therapeutic doses only

About the SELECT Trial 7 SELECT was a randomized, double-blind, parallel-group, placebo-controlled trial designed to evaluate the efficacy of semaglutide 2.4 mg versus placebo as an adjunct to standard of care for prevention of major adverse cardiovascular outcomes (MACE) in people with established cardiovascular disease with overweight or obesity with no prior history of diabetes

In the later period, new users in both SGLT2i and GLP-1 RA cohorts were older, use of medications for type 2 diabetes was less intensive, and metabolic control was better, and although more patients had renal function assessed, patients had more severe CKD (stage 3: 44.052.1% vs

In males, body weight was numerically decreased ( P = 0.163) while lean mass was significantly reduced with mAb treatment (Supplementary Fig