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These changes are largely the result of : - Rapid weight loss - Significant loss of muscle and connective tissue - Reduced structural support under the skin The Result : - Sagging facial skin - Sunken cheeks - Flattened or loose gluteal tissue - Accelerated appearance of aging This is not simply fat loss it is loss of tissue integrity, which becomes more noticeable when muscle mass is stripped away

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Platelet dysfunction plays a central role in building up the cardiovascular risk of diabetic patients, since T2D is characterized by an enhanced thrombotic state related to endothelial dysfunction, activation of the coagulation cascade and increased platelet reactivity (Murcia et al., 2004

Because platelets are cell fragments, they are also good at making a scaffolding or framework for healing in areas of damaged tendons or ligaments