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Driving and inhibiting ferroptotic mechanisms Ferroptosis, a type of non-apoptotic cell death, is characterized by three main processes that affect the sensitivity of cells to ferroptosis: (1) an increase in the content of free iron that generates ROS through the Fenton reaction, (2) a depletion of the antioxidant glutathione (GSH) and a loss of glutathione peroxidase 4 (GPX4) activity, and (3) an accumulation of lipid peroxidation products and a disruption of cell membranes [12]

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