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demonstrated greater survival, preserved LV function, decreased myocyte apoptosis and reduced caspase-3 activation on chronic GLP-1 infusion in spontaneously hypertensive, heart failure prone rats [74]
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What they found: Erectile response in 80 % of subjects in the Melanotan II group vs 20 % placebo Mean time to erection: 45 minutes Mean duration of erection: 90 minutes Subjectively satisfactory penetrative capability in 70 % Nausea in 50 % of subjects Why it matters: This was the first clinical demonstration of the melanocortin mechanism for erectile function
Why It Matters: Competes strongly in the oral GLP-1 race, alongside semaglutide (oral 2.0), Lillys orforglipron, and emerging small-molecule programs
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