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The FDA permits compounding when patients cannot access FDA-approved alternatives due to allergies to inactive ingredients, need for a different dosage form (such as liquid instead of pills), or medication shortages
Common side effects include nausea, vomiting, diarrhea, constipation, and stomach discomfort, particularly at the start of treatment
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Certain factors may increase the likelihood of experiencing bloating on GLP-1 therapy, including: Pre-existing gastrointestinal conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or small intestinal bacterial overgrowth (SIBO) Rapid dose escalation without adequate titration periods Dietary factors , particularly high intake of fermentable carbohydrates (FODMAPs), fatty foods, or carbonated beverages Concurrent medications that affect gastrointestinal motility Patients should be aware that GLP-1 receptor agonists have been associated with more serious gastrointestinal adverse effects, including pancreatitis (inflammation of the pancreas) and gallbladder disease
