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After talking to hundreds of patients with obesity over the years and to clinicians and researchers who study the disease, let me assure you: Reality looks a lot less like free will. Weight gain and weight loss are a complex orchestra of hormones that tell the body when were hungry and when were full

These data support that selectivity based on target-cell antigen density can be tuned through changes in monovalent affinity and avidity, which may reduce on-target, off-tissue toxicities