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A 2024 systematic review and meta-analysis suggested NAC may be helpful as an add-on therapy for adults with moderate-to-severe OCD, but results have not been consistent across all psychiatric conditions or studies.33 Researchers are still working to determine which patients are most likely to respond and whether NAC's benefits are large enough to produce meaningful improvements in day-to-day functioning

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Pharmaceuticals used to treat diabetes, schizophrenia, and other psychiatric diseases cause QTc prolongation

Additionally, baseline metabolic health, insulin sensitivity, stomach motility, and concurrent medications affect efficacy and tolerability