can't lose weight on semaglutide 12 Reasons You're Not Losing Why am I not losing

6 Alternatively, some patients may be prescribed sulfonylureas or thiazolidiniones to improve insulin secretion, but both of these treatment options are associated with an elevated risk of heart failure making them unsuitable for use in patients with cardiovascular disease

10.1210/jc.2006-1806 25 GoldsteinA

Compounding pharmacies provided a lower-cost alternative during the drug shortage period, but FDA removal of semaglutide and tirzepatide from the shortage list in late 2024 and early 2025 ended most compounding

There is currently no evidence suggesting that post-cholecystectomy patients experience increased tirzepatide-related adverse effects compared to those with intact gallbladders