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This suggests that a resistance exercise-related mechanism of inducing plasma NO, perhaps due to increased shear stress that triggered an up-regulation in NO-cGMP signaling along with a slow, sustained release of NO from GSH + CIT, may be a conceivable candidate for this response

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The Lancet (2023) 6

Chairs Summation Prof Thci concluded by discussing the future research needed regarding the broad effects of fumarates in psoriasis and how both this class of drugs and IL-23 inhibitors should be considered for use in long-term therapy.