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Since the compound is only present in animal-based foods, the task of having a high enough supply of vitamin B12 is especially difficult for vegans and vegetarians
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Meanwhile, Parkin is involved in the regulation of mitochondrial biogenesis via PARIS, a transcription factor that negatively regulates PGC1a and its target NRF1 or directly enhances TFAM-mediated mitochondrial transcription in proliferating cells (Shin et al., 2011)
Yoshikawa K et al
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